N-(4-AMINOPHENYL-SULFONYL)ACETAMIDE SODIUM SALT HYDRATE
Sulfacetamide sodium
CAS: 6209-17-2;127-56-0
Molecular Formula: C8H13N2NaO4S
N-(4-AMINOPHENYL-SULFONYL)ACETAMIDE SODIUM SALT HYDRATE - Names and Identifiers
N-(4-AMINOPHENYL-SULFONYL)ACETAMIDE SODIUM SALT HYDRATE - Physico-chemical Properties
| Molecular Formula | C8H13N2NaO4S |
| Molar Mass | 256.25 |
| Melting Point | 263-265°C |
| Boling Point | 450.8°C at 760 mmHg |
| Flash Point | 226.4°C |
| Water Solubility | Freely soluble in water. Insoluble in chloroform, ether, and benzene. |
| Solubility | Easily soluble in water, slightly soluble in ethanol, slightly soluble in acetone. |
| Vapor Presure | 6.51E-09mmHg at 25°C |
| Appearance | White crystalline powder |
| Color | white to off-white |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| MDL | MFCD00149555 |
| In vitro study | Sulfacetamide inhibited Arabidopsis DHPS,IC50 = 9.5 μm, pKa = 5.4. Sulfacetamide induces antiproliferative effects in T-47D cells independent of apoptosis and cell cycle arrest. Sulfacetamide decreased the expression of p53/DRAM pathway, and upregulated Akt/mTOR signaling, promoting autophagy. Sulfacetamide has an LD50 of 41 mM in T-47D cells (48 hours of treatment) and does not cause DNA fragmentation. In sulfacetamide-treated cells, ATG5 expression was upregulated, indicating an increase in autophagosome formation. The autophagy response induced by Sulfathiazole and sulfacetamide was not accompanied by apoptosis and cycle arrest. The autophagy response it elicits in T-47D cells does not depend on the DAPK signaling pathway. Sodium sulfacetamide or sulfacetamide is a bacteriostatic agent that is used in Gram-negative and positive bacteria sensitive to sulfonamide (including Streptococci, Staphylococci, E. coli, Klebsiella pneumoniae, Pseudomonas pyocyanea, Salmonella spp., proteus vulgaris, Nocardia) is active. Sulfacetamide inhibits mannose-6-phosphate isomerase(PMI: phosphomannose isomerase), a key enzyme in kinetic energy metabolism. |
| In vivo study | The LD50 of sulfacetamide administered by oral route in mice is 16,500 mg/kg. In humans, side effects include erythema, moderate swelling, nausea, vomiting, and headache. In addition to these side effects, there have been reports of StevensJohnson syndrome in HIV-positive patients using sulfacetamide drops to treat eye infections. However, most of these side effects are caused by the high absorption of the drug through the oral route or through the skin, mucosa and conjunctiva, while topical use of sulfacetamide does not show strong side effects. |
N-(4-AMINOPHENYL-SULFONYL)ACETAMIDE SODIUM SALT HYDRATE - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37 - Wear suitable gloves. |
| WGK Germany | 3 |
| RTECS | AC8480000 |
| HS Code | 29350090 |
N-(4-AMINOPHENYL-SULFONYL)ACETAMIDE SODIUM SALT HYDRATE - Introduction
Easily soluble in water, slightly soluble in ethanol, slightly soluble in acetone. Bug-free, slightly bitter taste.
Last Update：2022-10-16 17:27:17
Supplier List
Spot supply
Product Name: Sulfacetamide sodium Request for quotationCAS: 6209-17-2
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Product Name: Sulfacetamide sodium Request for quotation
CAS: 6209-17-2
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
CAS: 6209-17-2
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Product Name: Sulfadimidine Impurity 5 Sodium Salt(Sulfadiazine EP Impurity E Sodium Salt) Request for quotation
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple Specifications
Product Name: Sulfacetamide sodium Request for quotationCAS: 127-56-0
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Multiple SpecificationsSpot supply
Product Name: Sulfacetamide sodium salt hydrate Visit Supplier Webpage Request for quotationCAS: 127-56-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Sulfacetamide sodium Request for quotationCAS: 6209-17-2
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Product Name: Sulfacetamide sodium Request for quotation
CAS: 6209-17-2
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
CAS: 6209-17-2
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Product Name: Sulfadimidine Impurity 5 Sodium Salt(Sulfadiazine EP Impurity E Sodium Salt) Request for quotation
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple Specifications
Product Name: Sulfacetamide sodium Request for quotationCAS: 127-56-0
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Multiple SpecificationsSpot supply
Product Name: Sulfacetamide sodium salt hydrate Visit Supplier Webpage Request for quotationCAS: 127-56-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History